Evaluation of anti arthritic activity of solanum nigrum in complete freund’s adjuvant induced rheumatoid arthritis

Abstract

OBJECTIVE: Evaluation of Anti arthritic activity of Solanum nigrum in complete freund’s adjuvant induced arthritis model in rats. MATERIALS AND METHODS: Arthritis was induced in wistar albino rats by a single sub plantar injection of Complete Freund’s Adjuvant (CFA) into the left footpad. Rats were treated with prednisolone (10 mg/kg, p.o.) and Solanum nigrum (200, 400, 600 mg/kg, p.o.) from day 0 to 20. The effects of Solanum nigrum was evaluated by change in paw volume, body weight , detection of serum rheumatoid factor (RF), serum C-reactive protein level, Alkaline phophatase, haemotological parameter , SGOT and SGPT level. Results: Results showed that Solanum nigrum significantly reduced paw volume, body weight, rheumatoid factor, C-reactive protein level, alkaline phophatase, WBC count, SGOT and SGPT level. CONCLUSION: The present results provide clear evidence that the methanolic extract of Solanum nigrum treatment gives anti-arthritic effect in complete Freund’s adjuvant induced rheumatoid arthritis.