Evaluation of nephroprotective activity of morus alba in gentamicin induced nephrotoxicity in rats

Abstract

Objectives: To Evaluate the Nephroprotective Activity of Methanolic Extract of Morus alba in in Gentamicin induced Nephrotoxicity in Rats Material and methods: In these model of nephrotoxicity, 36 Adult male wistar rats were divided in to 6 groups. In which group-1 and group-2 served as a normal control and positive control respectively. Where as a group-3 served as a standard group which receive prednisolone 10mg/kg and group-4, 5, and 6 was a treatment group which receive methanolic extract of Morus alba which were treated with the dose of 200 mg/kg, 400 mg/kg and 600 mg/kg respectively. After the experimental period blood sample were collected for serum parameter and Kidney was for Biochemical parameter and Histopathological study Results: Gentamicin treatment caused Nephrotoxicity as evidenced by marked elevation in Blood urea nitrogen, Uric acid and creatinine. Co-administration Methanolic extract of Morus alba with gentamicin decrease in Blood urea nitrogen, Uric acid and creatinine. Apart from these Histopathological changes also showed protective nature of Morus alba against gentamicin induced necrotic damage of renal tissue. Conclusion: It was observed that methanolic extract of Morus alba conferred nephroprotective and anti-oxidant activities by Histopathological and biochemical observation against gentamicin induced nephrotoxicity in rats.