Abstract:
Objectives: To Evaluate the Nephroprotective Activity of Methanolic Extract of Morus
alba in in Gentamicin induced Nephrotoxicity in Rats
Material and methods: In these model of nephrotoxicity, 36 Adult male wistar rats were
divided in to 6 groups. In which group-1 and group-2 served as a normal control and positive
control respectively. Where as a group-3 served as a standard group which receive
prednisolone 10mg/kg and group-4, 5, and 6 was a treatment group which receive methanolic
extract of Morus alba which were treated with the dose of 200 mg/kg, 400 mg/kg and 600
mg/kg respectively. After the experimental period blood sample were collected for serum
parameter and Kidney was for Biochemical parameter and Histopathological study
Results: Gentamicin treatment caused Nephrotoxicity as evidenced by marked elevation in
Blood urea nitrogen, Uric acid and creatinine. Co-administration Methanolic extract of Morus
alba with gentamicin decrease in Blood urea nitrogen, Uric acid and creatinine. Apart from
these Histopathological changes also showed protective nature of Morus alba against
gentamicin induced necrotic damage of renal tissue. Conclusion: It was observed that methanolic extract of Morus alba conferred
nephroprotective and anti-oxidant activities by Histopathological and biochemical
observation against gentamicin induced nephrotoxicity in rats.
