Abstract:
Lornoxicam is an oxicam derivatie and NSAID drug, used in treatment of Rheumatoid
arthritis. It is a highly bitter and hence not suitable for geriatric and pediatric patients.
In the present work an attempt was made to prepare taste masked suspension of Lornoxicam
using a simple rapid and cost effective method like complexation with ion exchange resin .
Complexation was done using ion exchange resin like kyron T-114 and kyron T-104. The
complexes were evaluated for drug loading, particle size, taste masking. The optimize complex
was formulated into a suspension. The prepared suspensions were evaluated for drug content,
particle size, viscosity, sedimentation volume, drug release and stability studies. Kyron T 114
with drug ratio of 1:3 was found mask the taste satisfactorily. The particle size and drug
loading of complex was 30-160 μm and 90.78% respectively. All the drug was release within 70
minutes.The assay, particle size, viscocity, pH ,zeta potential and sedimentation volume of
suspension was found to be 96.5% ,20-210 μm,2680 cps,7.2,-9.76 mV and 0.94.respectively. The
formulations were stable after one month of stability studies.,
