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Formulation and Evaluation of Solid Dispersion of Anti - Epileptic Drug

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dc.contributor.author Patel, Aiyub
dc.date.accessioned 2020-11-07T09:52:09Z
dc.date.available 2020-11-07T09:52:09Z
dc.date.issued 2013-05-01
dc.identifier.uri http://ir.paruluniversity.ac.in:8080/xmlui/handle/123456789/7360
dc.description For Full Thesis Kindly contact to respective Library en_US
dc.description.abstract The aim of the present investigation was to formulate and evaluate solid dispersion based capsule formulation for oral drug delivery of lamotrigine to increase the solubility and bioavailability. For the formulation of solid dispersion polymers such as B-cyclodextrine, PVP K-30, PEG 6000, Poloxamer 188 were selected. The solid dispersion prepared by solvent evaporation method and physical mixture method. The effect of changing the type of polymer ratio (1:1, 1:2, 1:3,.) on the formulation of solid dispersion was investigated. The 1:7 ratio was selected because it was gave higher solubility and drug release. The optimized solid dispersion contain 25mg Lamotrigine, PVP K-30 and PEG 6000 in ratio of 1:7, 0.1% Dioctyle sodium sulphosuccinate, 95% methanol. The prepared solid dispersion evaluated for various physio-chemical studies such as flow property, angle of repose, XRD study, DSC study, residual solvent study, saturation solubility, drug content, drug release.The F17 batch shown 1.856±0.344 mg/ml saturation solubility and 87.88 % drug release. The optimized solid dispersion based capsule was evaluated for saturation solubility, content uniformity, weight variation, drug content and in-vitro release study.The results of above all studies shown that solid dispersion based capsule of Lamotrigine having higher solubility and drug release. The release study of optimized solid dispersion was compared with marketed Lametec (25mg) tablet. It showed that solid dispersion based capsule was successfully formulated for increase in solubility and bioavailability of lamotrigine. en_US
dc.language.iso en en_US
dc.publisher Parul University en_US
dc.subject 112140810024 en_US
dc.subject Lamotrigine, Solid dispersion, Solvent evaporation method, Polyvinyl pyrrolidone K 30, Polyethylene glycol 6000, Saturation solubility, Oral Drug Delivery. en_US
dc.title Formulation and Evaluation of Solid Dispersion of Anti - Epileptic Drug en_US
dc.title.alternative 112140810024 en_US
dc.type Thesis en_US


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