Abstract:
The aim of the present investigation was to formulate and evaluate solid dispersion
based capsule formulation for oral drug delivery of lamotrigine to increase the
solubility and bioavailability. For the formulation of solid dispersion polymers such
as B-cyclodextrine, PVP K-30, PEG 6000, Poloxamer 188 were selected. The solid
dispersion prepared by solvent evaporation method and physical mixture method. The
effect of changing the type of polymer ratio (1:1, 1:2, 1:3,.) on the formulation of
solid dispersion was investigated. The 1:7 ratio was selected because it was gave
higher solubility and drug release. The optimized solid dispersion contain 25mg
Lamotrigine, PVP K-30 and PEG 6000 in ratio of 1:7, 0.1% Dioctyle sodium sulphosuccinate,
95% methanol. The prepared solid dispersion evaluated for various
physio-chemical studies such as flow property, angle of repose, XRD study, DSC
study, residual solvent study, saturation solubility, drug content, drug release.The F17
batch shown 1.856±0.344 mg/ml saturation solubility and 87.88 % drug release. The
optimized solid dispersion based capsule was evaluated for saturation solubility,
content uniformity, weight variation, drug content and in-vitro release study.The
results of above all studies shown that solid dispersion based capsule of Lamotrigine
having higher solubility and drug release. The release study of optimized solid dispersion was compared with marketed Lametec (25mg) tablet. It showed that solid
dispersion based capsule was successfully formulated for increase in solubility and
bioavailability of lamotrigine.
