Formulation and evaluation of polymeric pseudolatices Bearing acetazolamide for the management of glaucoma

Abstract

The aim of the present investigation was to develop topical polymeric colloidal dispersion of Acetazolamide for management of glaucoma and to reduce the side effects of the drug and to prolong the release. Ethylcellulose and Polyvinyl pyrollidone K-30 were used as polymer to control the release.Tween-80 was used as emulsifying agent and liquid paraffin was used as oil phase. The results of FT-IR spectroscopy indicated the stable character of Acetazolamide and revealed absence of drug polymer interaction. Polymeric pseudolatices were evaluated for pH, viscosity, Average particle size, Drug content, and Diffusion. The particle size of the pseudolatices was in the range of 7-12 μm. The in vitro drug release study showed that Acetazolamide release from the pseudolatices was slow and sustained for 24 hrs. Batch F8 showed excellent release of drug. The in-vitro drug release from optimized formula was found to be 99.21 at 24 hrs. No irritation was found in the eye of rabbit and reduction in IOP was significant in rabbit eye. Formulation was remain stable during short term stability testing of 1 month, hence, polymeric colloidal dispersion of acetazolamide could prove to be a better alternative than conventional dosage form and better therapeutic efficacy.