Abstract:
The aim of the present investigation was to develop topical polymeric colloidal
dispersion of Acetazolamide for management of glaucoma and to reduce the side
effects of the drug and to prolong the release. Ethylcellulose and Polyvinyl
pyrollidone K-30 were used as polymer to control the release.Tween-80 was used as
emulsifying agent and liquid paraffin was used as oil phase. The results of FT-IR
spectroscopy indicated the stable character of Acetazolamide and revealed absence
of drug polymer interaction. Polymeric pseudolatices were evaluated for pH,
viscosity, Average particle size, Drug content, and Diffusion. The particle size of the
pseudolatices was in the range of 7-12 μm. The in vitro drug release study
showed that Acetazolamide release from the pseudolatices was slow and sustained
for 24 hrs. Batch F8 showed excellent release of drug. The in-vitro drug release from
optimized formula was found to be 99.21 at 24 hrs. No irritation was found in the eye
of rabbit and reduction in IOP was significant in rabbit eye. Formulation was remain
stable during short term stability testing of 1 month, hence, polymeric colloidal
dispersion of acetazolamide could prove to be a better alternative than conventional
dosage form and better therapeutic efficacy.
