Abstract:
Background:
Obsesseive and Compulsive Disorder or OCD is a heterogeneous and multidimensional
disorder. The lifetime prevalence of OCD in general population is 2-3%. This is the fourth
most common psychiatric diagnosis. It constitutes 10% of psychiatric OPD. The Standard or
proven drug for the OCD is yet to explored in the field of Ayurveda, though few studies has
been conducted but outcomes are not satisfactory.
Objective:
To evaluate the efficacy of Kalyanaka Ghrita in the management of Obsessive Compulsive
Disorder.
Method:
Ethical clearance:
Ethical clearance was obtained from Institutional Ethics Committee of Parul Institute of
Ayurved, Parul University, Vadodara – 391760. Vide Ref- PIA/IECHR/2016-17/KC/04
dated 22/10/16.
10 patients of OCD satisfying the DSM-IV diagnostic criteria were selected. Kalyanaka
Ghrita was administered to all for 60 days of period. The use of drug is in practice since very
long, explained in Ayurvedic classics for various diseases, especially in Unmada. This drug
was given for 60 days and patient then followed for one more month. There were total three
assessments done before treatment, after treatment and after follow up. Yale Brown
Obsessive Compulsive scale (Y-BOCS) was the selected for the measurement and Yale
Brown Obsessive Compulsive symptoms checklist was selected to identify the symptoms.
Results:
Contamination Obsession, Symmetrical Obsession, Religious Obsession, Cleaning/Washing
Compulsions, checking compulsions, Counting Compulsion, Ordering/Arranging
Compulsions are the commonest symptoms of clinical presentation of OCD. Paired‘t’ test
was used for statistical evaluation. 44.21% of relief was highly significant on reducing the
symptoms of OCD on Y-BOCS (p<0.001).
Interpretation:
By understanding of Etiology, Symptomatology, Pathology, Course of Disease, Prognosis
and Co-morbidity of OCD- the most suitable resemblance of OCD in Ayurveda is
Grahonmada or Bhootonmada, no any other conditions.
In present study it was found that almost every patients responded positively in short course
of treatment and the positive effect the continued even after stopping the treatment in follow
up period this may be because of long term and cumulative effect of the drug.
After the complete follow up period the overall reduction of all symptoms was highly
significant (about 44% reduction on Y-BOCS Score). This suggests Kalyanaka Ghrita is
Highly Significant in the management of OCD.
Conclusion:
It is concluded that the efficacy of Kalyanaka Ghrita is statistically and clinically significant
in the management of Obsessive Compulsive Disorder.