A clinical study of dhanayaka gokshuradi ghrita kshara basti in themanagement of the mootraghata w.s.r to benign prostatic hyperplasia

Abstract

Introduction: The BPH is an old age-related disorder in men which involves the growth of the prostatic gland, situated at the emergence of urethra i.e. the base of the urinary bladder. The growth / neoplastic changes in the prostatic gland occur due to the changes in the level of hormones especially androgens & estrogens. As per the aetiopathogenesis of mootraghata is concerned, there is deranged function of apana vayu along with the vitiation of kapha & pitta which produces ama and ultimately causes srotoavarodha. The vitiated doshas travel through sukshma srotasa & finally lodge in basti, where upon further vitiation of apana vayu leads to Mootraghata. In Modern system of medicine treatment of BPH is very costly. Hence, there is a need of the time to find an alternate treatment for the condition. With Ayurveda it can be treated effectively and with less cost. Materials and Methods : It is a clinical study with pre-test and post-test design conducted on thirty patients, Dhanayaka Gokshura Ghrita along with Yavakshara matra basti were given in a dose of 30 ml just after lunch. The time period for the study was 7 days and patients were followed up for a period of 1 month. Assessment was done on the basis of subjective and objective (USG, PURV, UFR) criteria. Ethical clearance was obtained from Institutional Ethics Committee (IEC No. PU/PIA/IECHR/SHALYA/05), and this study is registered in Clinical Trial Registry of India (REF/2017/10/015621). Results : The change in the values before and after the treatment were assessed by the paired ‘t’ test . In this study 61.11% patients got marked improvement in overall effect of therapy. 60% patients were had marked improved in subjective criteria (signs and symptoms) and 46.67% patients got marked improvement in objective parameters showed significant or highly significant results. Discussion : Dhanayaka gokshura ghrita matra basti with yavakshara showed better effect in breaking samprapti of mootraghata caused by vitiated vatakapha and equivalent pathophysiology described for BPH. Vata is always compared with all neuro-hormonal functions of body like regulation of normal growth & physiology of prostate & bladder. Hence, it can be inferred that matra basti normalizes the functions of apana vayu leading to normal mootra pravriti and removal of aghata from mootravaha srotasa and satisfactory and significant result were observed during study. Conclusion: The hypothesis that the drug ‘Dhanayaka Gokshura Ghrita matra basti with Yavakshara’ has beneficial effects on Mootraghata w.s.r. to BPH, is accepted and the null hypothesis is rejected.