Abstract:
Introduction: Vandhyatva is presently a leading and longstanding gynaecological issue affecting approximately 15% of the couples in reproductive age group around the globe while 10-15% in Indian population. Ovulatory dysfunctions form the major cause of female infertility, out of which Anovulation accounts for 40%. Anovulation can be interpreted as Abeejotsarga or abeejata. The growing incidences of complications of ovulation inducing drugs of modern medicine necessitates the exploration of safer, cost-effective, holistic, yet fast acting formulations mentioned in Ayurveda classics. The present study, thus aimed at evaluating the ovulation inducing effect of Pushpadhanva Rasa by comparing it with Clomiphene citrate.
Methodology: The study was conducted among 30 female subjects, diagnosed of anovulation with either primary or secondary infertility, fulfilling the inclusion and exclusion criteria and were randomly allocated into two groups with 15 subjects in each. Group A received Pushpadhanva Rasa Vati (250 mg BD, with Kshira, Madhu, Sharkara in Apana Kala, from 1st day of menses till 20th day ), while Group B were administered with Tab. Clomiphene citrate (50mg OD, from day 2 of menses, for 5 days) for a period of three menstrual cycles. The assessment of results was done by follicular study conducted from 9th day of menstrual cycle till 20th day of every cycle for consecutive three cycles.
Results: Both the groups showed significant improvement in assessment parameters. Ovulation was observed in 40% of subjects in Group A and 53.3% of subjects in Group B.
Discussion: Tridoshahara property of all dravyas resulted in normalcy in functioning of beejotpatti and beeejotsarga. Panchavata niyamana property of Rasasindoora and Vatashamaka property of other dravyas showed effect on regulation of H-P-O Axis. Abhraka, Naga and Vanga bhasmas had direct effect on prajanana sansthana and beejagranthi by virtue of prabhava. Neuroendocrinal stimulatory effect of Dhattura, Bhanga, Nagavalli; Garbhashaya and Basti Sankochana property of Bhanga and Yashtimadhu being Agnimandyahara and Vata Shamaka acted as effective catalysts.
Conclusion: Though Pushpadhanva rasa showed comparatively less percentage of improvement, its merits weigh more than that of CC in terms of absence of side effects like multiple pregnancy, OHSS etc.
