Abstract:
The inhibition of acetylcholinesterase (AChE) is considered as best strategy for the
treatment of Alzheimer’s disease (AD). In this study some possible interactions between
the receptor acetylcholinesterase AChE and some neuroprotective agents are reported
through molecular docking. Results of the docking study shows effective binding with the
receptors. Simultaneous identification and quantification of flavonoids was carried out
using simple, rapid, accurate and sensitive HPLC method in some herbal formulations.
The proposed method was successfully applied in the simultaneous determination of five
flavonoids in several herbal preparations selected from the local pharmacy and from
online market. The flavonoids were analyzed using C18 column in a gradient elution with
acetonitrile and buffer ammonium acetate with the flow rate of 1.0 ml min–1 with UV
detection at 350 nm. The HPLC method was completely validated.
