Abstract:
Diabetes mellitus is a chronic disease characterized by derangements in carbohydrate, fat and protein metabolism. It is a
clinical condition characterized by increased blood glucose level (hyperglycemia) due to insufcient or inefcient
insulin. It is a most common metabolic disorder in India. Diabetic nephropathy is currently one of the leading causes of morbidity and mortality
in diabetic population, accounting for greatest proportion of end stage renal disease worldwide.
In Ayurveda Prameha is usually correlated with Diabetes Mellitus with important symptoms like Prabhoota Mutrata i.e Increased frequency
and quantity of urine and Avila Mutrata which means turbid urine. Prameha is considered as Chirakaaleena vyadhi(chronic disease) which is
Anushangi1(recurring) in nature. It is due to vitiation of tridoshas (vata-pitta-kapha) especially Kapha dosha which can be considered as
important components of protoplasm2 which governs all the activities of body and also symbolizes the physico-biological properties of
compounds made through a different combination of Panchamahabhootas i.e Akasha(space), Vayu(electrons), Teja(energy), Jala(proton) and
Prithvi(neutron)3.GFR (Glomerular ltration rate) is considered as the best indicator of overall kidney function and therefore its assessment has
become an important clinical tool in daily patient care. A stepwise increase in nitrogenous constituents of blood like urea, creatinine etc and other
biochemical parameters like albumin, electrolytes etc also believed to reect deteriorating kidney function. Cystatin-c4 is one among Renal
Function Tests. It is done to detect chronic kidney dysfunctions. It is considered as better marker for GFR than Serum Creatinine. Even in disease
Prameha(DM) Renal functions predominantly gets disturbed leading to many future complications. So the pivotal role of serum Cystatin-C as a
marker for early detection of renal dysfunction in Diabetes Mellitus will be discussed elaborately which may be benecial in decreasing the
incidence of patients landing up in complications especially related to renal system.