Development and Validation of Analytical Methods for Simultaneous Estimation of Dexamethasone and Sparfloxacin in Eye/Ear Drops

Rathod, Hetalkumari

dc.contributor.author	Rathod, Hetalkumari
dc.date.accessioned	2020-11-10T04:53:12Z
dc.date.available	2020-11-10T04:53:12Z
dc.date.issued	2013-05-01
dc.identifier.uri	http://ir.paruluniversity.ac.in:8080/xmlui/handle/123456789/7523
dc.description	For Full Thesis Kindly contact to respective Library	en_US
dc.description.abstract	A simple, accurate and precise UV Spectrophotometric method and RP-HPLC method was developed and validated for simultaneous estimation of Dexamethasone and Sparfloxacin in Eye/Ear drops. In UV spectrophotometric Q-absorption ratio method determination was carried out at 271.2 nm an Iso-bestic point of both the drug and 241.6nm which is maximum wavelength of Dexamethasone with linearity range 1-6 μg/ml for Dexamethasone and 3-18 μg/ml for Sparfloxacin. Both the drugs were found in good agreement with the label claimed in the marketed formulation. In the Eye/Ear drops both the drugs were estimated as 99.4% and 98.6% for Dexamethasone and Sparfloxacin respectively. In RP-HPLC method, separation for simultaneous estimation of Dexamethasone and Sparfloxacin was achieved on BDS hypersil C 18	en_US
dc.language.iso	en	en_US
dc.publisher	Parul University	en_US
dc.subject	112140804012	en_US
dc.title	Development and Validation of Analytical Methods for Simultaneous Estimation of Dexamethasone and Sparfloxacin in Eye/Ear Drops	en_US
dc.title.alternative	112140804012	en_US
dc.type	Thesis	en_US