Abstract:
Objectives: To Evaluate the Hepatoprotective Effect of Polyherbal Formulation in
Paracetamol induced Hepatotoxicity in Rats
Material and methods: In these model of Hepatotoxicity, 42 male adult male wistar rats
were divided in to 7 groups. Group-1 and Group-2 served as a Normal control and
positive control respectively, Group-3 served as a standard group (Liv. 52 5.2 ml/kg) and
Group-4, 5, and 6 group received polyherbal formulation with the dose of 100 mg/kg,
300 mg/kg and 500 mg/kg respectively prior to PCM and Group-7 received polyherbal
formulation followed by paracetamol treatment. After the experimental period blood
sample were collected for biochemical parameters and kidney was isolated for
histopathological studies. Results: Paracetamol treatment caused hepatotoxicity as evidenced by marked elevation
in AST, ALT, LDH, and total bilirubin. Co-administration of polyherbal syrup with
paracetamol showed decrease in AST, ALT, LDH, and total bilirubin. In addition,
Histopathological studies also showed protective nature of polyherbal syrup against
paracetamol induced hepatotoxicity.
Conclusion: It was observed that Polyeherbal syrup containing Allium sativum, Ocimum
sanctum, Curcuma longa, Aloe barbadensis conferred hepatoprotective and anti-oxidant
activities by histopathological and biochemical observation against paracetamol induced
hepatotoxicity in rats. In the near future polyherbal syrup could lead to discovery of novel
herbal combination drug for treatment of hepatotoxicity.
