Abstract:
The aim of the present investigation was to develop a Solid self-microemulsifying
drug delivery system(S-SMEDDS) to enhance solubility and dissolution rate of
Quetiapine Fumarate. The solubility of Quetiapine Fumarate was checked in different
oils, surfactants and cosurfactants and ternary phase diagrams were constructed to
evaluate the microemulsion domain. Final formulation for SMEDDS containing 2.5%
Capmul CMC EP, 50% Cremophore EL & Tween 20 and 47.5% water were
optimized by 32 factorial design and response surface modelling. SMEDDS were
characterized for % Transmittance, mean globule size, zeta potential, and %
Cummulative drug release. The optimized microemulsion was further evaluated for %
transmittance, dilutability, pH, viscosity, conductivity, drug content and stability
study. Diffusion rate of Quetiapine Fumarate was measured by in-vitro Dissolution
method by USP type II apparatuse using phosphate buffer (PBS) pH 6.8 as diffusion
media. Based on characterization and in-vitro release results optimize batch was
selected. Solid SMEDDS were prepared using colloidal silicon dioxide (Aerosil 200)
and microcrystalline cellulose (Avicel PH101) to adsorb the optimal liquid SMEDDS. S-SMEDDS were evaluated for powder characteristics and dissolution profile. The invitro
release of S-SMEDDS, SMEDDS and marketed tablet formulation were
compared. The globule size, zeta potential and % Cumulative drug release of optimal
SMEDDS were found to be 11.86nm, -11.67 mv and 96.64% respectively. The
quetiapine Fumarate S-SMEDDS showed maximum drug release 97.87% in 30 min
compare to liquid-SMEDDS and marketed formulation.
