Abstract:
In the present study, an attempt was made to develop Transdermal Patch of
Lornoxicam by solvent casting method. Drug-excipients incompatibility study was
carried out using Fourier Transform Infrared spectroscopy (FTIR) which shows that
drug and excipients were compatible to each other. Transdermal Patch of Lornoxicam
containing Hydroxy Propyl Methylcellulose K15M and natural polymer like Psyllium
and Guar Gum were developed by solvent casting method by using glycerin and PEG
400 as a Plasticizer and propylene Glycol as a permeation enhancer. An optimized
formulation P5 (Psyllium 50mg, HPMC K15M 150mg) was having excellent
appearance, transparency, % elongation (20.46±0.43), tensile strength (8.48 kg/cm2),
folding endurance (398±1.027) and ex vivo maximum drug release 93.14 % drug
within 24 h. Glycerin (40 % w/w of polymer) and PEG 400 (40%w/w of polymer)
was used as the plasticizer which gave good elasticity to the film. Stability studies of
an optimized batch showed no significant change in appearance, elasticity, folding
endurance and ex vivo drug release after storage at 40 ±2 oC and 75±5% RH and
30±2˚C and 65±5 % RH for a period of one month. This approach suggested that the
transdermal patch of Lornoxicam using Hydroxy Propyl Methylcellulose K15M and
psyllium gives control release for 24 h.