Abstract:
In the present study, an attempt was made to develop transdermal film of
Prochlorperazine maleate by solvent casting method intended for treatment of
chemotherapy induced nausea and vomiting and selection of most satisfactory
formulation by ex vivo evaluation. Drug-excipients incompatibility study was carried
out using Fourier Transform Infrared spectroscopy (FTIR) which shows that drug and
excipients were compatible to each other. transdermal film of Prochlorperazine
maleate containing Hydroxy Propyl Methyl cellulose K4M, Hydroxy Propyl Methyl
cellulose K15M and glycerin were developed by solvent casting method. An
optimized formulation was having excellent appearance, transparency, % elongation,
tensile strength, folding endurance and ex vivo drug release. Batch F8(4%)(50:50)
shows maximum ex vivo drug release with a maximum time. Glycerin (20 % w/w)
was used as the plasticizer which provide good elasticity to the film. Stability studies
of an optimized batch showed no significant change in appearance, elasticity, folding
endurance and in vitro drug release after storage at 40 ±2 oC and 75±5% RH and
30±2°C and 65±5 % RH for a period of one month. This approach suggested that the
transdermal film of Prochlorperazine maleate using Hydroxy Propyl Methyl cellulose
K4M(2%) and Hydroxy Propyl Methyl cellulose K15M(2%) gives more sustain
release action in around 12 hours and may decrease the dosing frequency of the drug
in management of chemotherapy induced nausea and vomiting.
