CLINICAL EVALUATION OF KATUPILA NIRUDHHALEPA IN MANAGEMENT OF DUSTHA VRANA

Abstract

INTRODUCTION: Dustavrana (Chronic/ non-healing/ contaminated ulcer) is a frequently encountered problem in present era commonly as a complication of trauma and pathological insult. Ayurveda has mentioned Dusta Vrana and its management very broadly. Among that Vrana Shodhana and Vrana Ropna is a treatment modalities which is mentioned under the Shasti Upkramas. Number of drugs known to Ayurveda since Vedic era is increasing time to time. Aacharya Charaka states that one should get the knowledge about plants from tribal people or cowherds as they know and use the plants in a better way by experience. So this study includes a drug Katupila, which can be easily available to all people and useful for Vrana Shodhana and Ropana. AIM AND OBJECTIVES: Aim –To evaluate the efficacy of Katupilla Nirudhhalepa in the management of DustaVrana Objective – • To assess the pathophysiology of Dusta Vrana in context of Ayurvedic literature • To evaluate the mode of action of Katupilla Nirudhhalepa in the management of Dusta Vrana. • Pharmacological evaluation of Katupila • To observe and compare the available classical Dusta Vrana lakshna with available modern parameters for the chronic wound ABSTRACT METHODOLOGY: A Open single arm Clinical Trial Study on minimum 30 patients of Dusta Vrana were treated with local application of Katupila Nirudhhalepa (Katupila Patra Churna and Honey) once in a day for maximum 28 days or till complete wound healing whichever is earlier. Baseline Assessment was done on day 0, and then weekly progress was assessed over Vedana, Sraava, Kandu, Gandha, Varna, Akruti, Granulation and Slough and was noted in clinical case proforma and it was statistically analysed after completion of study. OBSERVATIONS & RESULTS: The Statistical test showed significant results in the assessment parameters in study. Hence, null hypothesis is rejected and Alternative Hypothesis i.e. Katupila Nirudhhalepa is effective in management of Dusta Vrana is accepted. CONCLUSION: • Even though, in classics only single Sloka is mentioned for Dustha vrana, Dustha Vrana can be classified in tar-tama bhav as per Doshika involvement. • Shodhana property of Katupilla Nirudhhalepa is established by absence of necessity of mechanical debridement in all the 30 patients, though they have reported with different grading of slough. • Ropana property is indicated by pharmacological evaluation, that it consists many of ingredient i.e. alkaloids, terpenoids, flavanoids etc and also antibacterial activity which are promoting factors for wound healing process. So, all observation and results showed that Katupila Nirudhhalepa is promoting agent in wound healing process. • Vrana is vast term including both wound and ulcer. And modern science has mentioned various type of non-healing, chronic and contaminated wound which can be considered under term Dusta Vrana. • No any adverse effects were noted during study, so conclusion can be drawn that, this combination is safe for local application in wound.