AN EXPERIMENTAL EVALUATION OF EFFECT OF SARPA NIRMOKA MASI ON VRANA

Abstract

INTRODUCTION: In the present day scenario healing of wound has become a nightmare for both surgeon and sufferer. Even though many methods have been mentioned in the classics regarding the matter but lacks feasibility in present times hence, a more efficient drug have been selected from the classics which is not widely used due to the procurement ABSTRACT NAME OF GUIDE, DESIGNATION : Dr. Vivekanand kullolli, of its raw materials and modified to a form which makes it more efficient in less doses and a pre-clinical study was conducted to revalidate its efficacy in the new dosage form. AIM AND OBJECTIVES: • To evaluate the wound healing potentials of Sarpa Nirmoka Masi on Vrana by means of experimental study. • To evaluate the pharmacological action of Sarpa Nirmoka Masi. • To assess the cost effectiveness of Sarpa Nirmoka Masi. • To evaluate the effect of Sarpa Nirmoka Masi in different types of wound. METHODOLOGY: DESIGN: Open single arm experimental study SETTING: Animal house attached to the Parul institute of pharmacy SELECTION: A total of 8 adult healthy male wistar rats of 08-10 weeks old age were selected. The rat body weight was in the range of 260 to 290 gms. GROUPING: Total 8 Animals were procured for this study, which were divided consisting of 2 animals in each group (NORMAL, CONTROL, STANDARD, TRIAL-SHUDHA VRANA & DUSTA VRANA) PROCEDURE: A full thickness of the excision wound of approximate area of 700 sq.mm and 2mm depth were created along the markings with a surgical blade in control, standard and Trial groups INTERVENTION: Normal group: Not made any wound Control group: Wounds were left for natural healing without any medications Standard group: Wounds were treated with 5% povidone-iodine ointment Trial group (both Shudha Vrana and Dusta Vrana) : Wounds were treated with Sarpa Nirmoka Masi Film OBSERVATIONS & RESULTS: The days it took for the healthy granulation and epithelization to appear were 10 days in Shudha Vrana and 18 days on Dusta Vrana respectively. Where as it took 24 days in both Control and Standard groups. At the end of study Shudha Vrana and Dusta Vrana samples showed complete healing of wound on 14th and 18th day respectively. Where as it took Control and Standard groups 28 and 30 days. CONCLUSION: Sarpa Nirmoka Masi Film is effective in healing of Shudha Vrana and Dushta Vrana.