Abstract:
The aim of present study is to formulate and evaluate the orodispersible tablets of
Hydroxyzine hydrochloride using natural superdisintegrants. In this investigation
orodispersible tablets were prepared using different superdisintegrants like banana
powder, cassia tora powder and isabgol husk powder. The model drug chosen was
hydroxyzine hydrochloride, for antihistaminic action. Hydroxyzine hydrochloride
tablets were prepared using different concentration (1%, 2.5%, 5%, 7.5%, 10%) of
superdisintegrant by the direct compression method. The solid state property of
orodispersible tablet powder blend was characterized by Fourier transform infrared
spectroscopy (FTIR) studies of hydroxyzine hydrochloride and mixture of all
excipient were confirmed that the drug was pure and there is no chemical interaction
between drug with all excipients. The prepared orodispersible tablets were evaluated
for various parameters for Precompression as well as post compression such as drug
content, hardness, friability and disintegration time. Among all the formulations,
Batch F4 containing ratio of cassia tora and Isabgol powder (7.5% and 5%w/w) of
natural superdisintegrant showed good wetting time and disintegrating time as
compared all other formulation. The lowest disintegration time was found with the
batch F4. Thus, Batch F4 optimized as final formulation. The tablets were found to be
stable during the accelerated stability studies conducted for one month of duration at
40 ± 20c and 75 ± 5% R.H.
