Abstract:
Periodontal disease is a severe gum infection that damages the soft tissues and
destroy the bone and supports your teeth. Periodontal Disease is very common
and, is widely severe as the second most common disease worldwide. In the
united states has a prevalence of 30-50% of the population, but about have
severe form. This severe form is known as periodontitis. Caffeine shows
antimicrobial and potent antioxidant activity and used to treat certain bacterial
infection. Common side effect of caffeine includes Nausea, vomiting,
hypertension, Rapid heartbeat and digestive issue. Nanoparticles loaded film
contain chitosan and caffeine, Caffeine has a longer half-life 5-6 hours,
Nanoparticles loaded film is much efficient to deliver small amount of Drug
over prolonged period there by increasing patient compliance. Chitosan
containing nanoparticles prepared by ionic gelation method. The Optimized
batch of nanoparticles was evaluated for particle size, Zeta potential, Drug
content, In-vitro Drug release study, antimicrobial study, and Transmission
electron microscopy. Drug content and Drug release of optimized batch F3
were 86.40% and 89.30% respectively. Transmission electron microscopy
(TEM) study shows that the particles size and Particle shape, after preparation
of Nanoparticles they have loaded in film. Nanoparticles loaded film was
prepared by solvent casting method using ethyl cellulose as polymer. The film
was evaluated for thickness, weight uniformity, swelling index, folding endurance, surface pH, and surface morphology study with Gas
chromatography, antibacterial study. Drug content and folding endurance of
optimized batch were 81.22% and 312 respectively. Chitosan containing ethyl
cellulose loaded film combination is the improved carrier including other
preparation of caffeine periodontal film for prolonged the drug action up 7
days.