Abstract:
Objective: The objective of the present study was to evaluate cardio-protective
potential of Empagliflozin and Linagliptin respectively and their combination in
experimentally induced cardiotoxicity in rats.
Method: Animals were divided into Five groups of six animals in each. Group I served
as normal control group and received vehicle (0.5% carboxy methyl cellulose) for 15 days.
Group II served as Disease control group and received Isoproterenol (85mg/kg, s.c.) on
14th and 15th days. Group III served as Drug treated group and received Empagliflozin
(10mg/kg/day, p.o.) for 15 days and Isoproterenol (85mg/kg, s.c.) on 14th and 15th days.
Group IV served as Drug treated group and received Linagliptin (5mg/kg/day, p.o.) for
15 days and Isoproterenol on 14th and 15th days. Group V served as Drug treated group
and received combination of Empagliflozin 10mg/kg + Linagliptin 5mg/kg, p.o. for 15
days and Isoproterenol (85mg/kg, s.c.) on 14th and 15th days. At the end of the treatment period, animals were anaesthetized with anaesthetic ether after
final drugs dose administration and then blood was collected from the retro-orbital plexus
for estimation of different biochemical parameters like blood glucose(BG), creatine kinase
MB(CK-MB), lactate dehydrogenase (LDH), Aspartate amino transferase, High
sensitivity C reactive protein (HSCRP), lipid profile, animals were euthanized and
hearts were isolated for Histopathological examination.
Result and Disussion: Animals treated with the Empagliflozin, Linagliptin alone and
combination of Empagliflozin+Linagliptin. In that we showed inhibition in the elevated
level of CK-MB, LDH, HSCRP, Troponin I and Lipid profile in drug treated groups. In
combination of Empagliflzin+Linagliptin showed more cardiorprotection as compared to
other drugs treatment.
Conlusion: Empagliflozin, Linagliptin and combination of Empagliflozin+Linagliptin
could have beneficial effects in cardiotoxicity and combination of both
Empagliflozin+Linagliptin showed more cardioprotection as compared to other drugs
