Abstract:
The present study is the continuation of a program aimed at investigation of phytochemical
properties of Andrographis paniculata leaf, stem, and root extract to justify the traditional
clain endowed upon this herbal drug as a rasayana in Ayurveda. Andrographis paniculata is
belongs to family of Acanthaceae and commonly known as Kalmegh, King of better and
Chirayata. It is a valuable traditional medicine plant. It was antibacterial, anti-fungal,
antioxidant antimicrobial, antidiabetic and antipyretic, hepatoprotective cardiovascular and
anti-virus including inhibited HIV properties. The plant commonly used by the local people,
for the treatment of common cold, fever, malaria, liver disease, snake bites, diabetes, and
some skin infections. Phytochemical screening of methanol, ethanol, petroleum ether, acetone
and chloroform, distilled water extract of leaves and stem bark of Andrographis paniculata
showed the presence of glycosides, phytosterol, saponins, tannins, flavonoids, and other. The
use of plant extracts for antimicrobial activity and other diseases have been observed to be
promising remedies since ancient time in Chinese and unani medicine and other. The use of
plant extracts with known antimicrobial properties can be of appreciable significance for
therapeutic treatment. The agar well diffusion method was followed to evaluate the
antibacterial activity of Andrographis paniculata against E. coli, presudomonas, aspergillus
niger, lacto bacillus, etc. and anti-fungal activity of Andrographis paniculata against candida
and others. The present investigation evaluate the potential antibacterial activity of
chloroform and methanol extract of Andrographis paniculata.