http://localhost:8080/xmlui/handle/123456789/7662 Sun, 12 Apr 2026 22:47:13 GMT 2026-04-12T22:47:13Z http://localhost:8080/xmlui/handle/123456789/8325 Antimicrobial utilization pattern among pediatric inpatients of a tertiary care hospital in Central Gujarat Patel, Nirav; Patel, Devanshu J; Desai, Haresh Background: Drug utilization studies may help to measure various aspects such as disease pattern, medicine use, and prescribing patterns. Aim and Objective: The aim of the study was to evaluate the drug utilization pattern of antimicrobials prescribed to the pediatric inpatients at a tertiary care hospital. Materials and Methods: The study was prospective and observational based involving 200 pediatric inpatients of Parul Sevashram Hospital, Vadodara, Gujarat. Relevant information was obtained from the interview as well the hospital case record. Structured and pre-tested formats were prepared for compiling the data. Results: The majority of the patients (43.5%) were in the age group between 2 and 12 years. The most common indications for antimicrobial use included gastrointestinal diseases (22%), respiratory diseases (17.5%), and genitourinary diseases (13.5%). Cephalosporins (65.5%) were most frequently prescribed antimicrobials followed by aminoglycosides (40%). 73.3% of antimicrobials were prescribed by branded names. The average number of antimicrobials prescribed per patient was 2.21. 93.4% of antimicrobials have been included in the World Health Organization Model List of Essential Medicines. A total of 13 adverse drug reactions were reported from prescribed antimicrobials. Conclusions: Medicine utilization assessment can facilitate rational use of medicines in pediatric patients. Tue, 01 Oct 2019 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/8325 2019-10-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8223 Review of Atypical Lipoma and its Natural Treatment Dasvani, Brijesh; Khristi, Avani; Thiyagarajan, Vanniyer Atypical lipomatous are rare tumors that typically arise out of soft tissues in the body and common in adults. Most lipomas comprise of mature fat cells that exhibit characteristic of benign tumor by nature. They are round, motile, non-painful slow growing masses, with a characteristic soft and soggy feel, usually appear in the hypodermic area of skin. Atypical lipomas, though uncommon and slow growing can be associated with syndromes such as multiple hereditary lipomatosis, colorless adipose, Gardner's syndrome and Madelung's disease. While surgery has been the primary treatment modality, doctors have managed few patients with radiation therapy (RT). Median age of diagnosis was found in the range: 36–76 years but intramuscular lipomas may occur irrespective of age group, right from childhood to old age. However, the occurrence dominancy was found between the ages of 42 and 72 years, with the average age at presentation reported as 47 to 57 years. Sun, 01 Sep 2019 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/8223 2019-09-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8220 RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF TENELIGLIPTINE HYDROBROMIDE HYDRATE (TEN) AND METFORMIN HYDROCHLORIDE (MET) IN TABLET DOSAGE FORM Joshi, H.; Khristi, A. A simple, accurate, precise, reproducible and economic method developed and validated for the simultaneous estimation of teneligliptine hydrobromide hydrate (TENE) and metformin hydrochloride (MET HCl) in pharmaceutical dosage form. TENE and MET HCl were estimated on Thermoscientific C18 column using mobile phase 0.01M PDP: methanol (45:55 % v/v) (pH 3.5 adjusted with 5% acetic acid) at flow rate 1.0 mL/min. Detection was carried out at 254 nm. The retention time of teneligliptine hydrobromide hydrate and metformin hydrochloride were 7.77 min and 2.64 min, respectively. The linearity was found to be 4-12 μg/mL and 100-300 μg/mL for TENE and MET HCl respectively. R2 value was found to be 0.998 and 0.995. For the assay method % recovery was found in the range of 98.16 – 101 for TENE and MET HCl. The LOD and LOQ were found to be 0.3527 and 1.0690 for TENE and 0.5077 and 1.538 for MET HCl respectively. Method was validated as per ICH guidelines. Tue, 01 Jan 2019 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/8220 2019-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8172 Formulation of Dry Powder Inhaler of Anti-tuberculous Drugs Using Spray Drying Technique and Optimization Using 23 Level Factorial Design Approach Thakkar, Vaishali; Pandey, Ekta; Pandya, Tosha; Shah, Purvi; Patel, Asha; Trivedi, Roma; Gohel, Mukesh; Baldaniya, Lalji; Gandhi, Tejal Background: Targeting anti-tubercular therapeutics to alveolar macrophages using microparticles technology mainly focuses on increasing local concentrations of therapeutics and potentially reducing the frequency of dosing requirements. Rifampicin (RIF), Ofloxacin (OFX) and Ethambutol (ETH) combination show synergism. Objective: In light of the above facts, the focus of the present study was to develop and characterize novel Dry powder Inhaler formulation incorporating novel drug combination as a pulmonary delivery for the effective eradication of Tuberculosis. Method: Biodegradable microparticles containing RIF, OFX and ETH were prepared by a spray drying technique using PLGA polymer through the critical process as well as polymer attributes were screened and optimized using 23 factorial design. The identified critical process parameters (CPP’s) viz. Inlet temperature, Aspiration rate, and feed rate were selected as independent variables while percentage yield, percentage entrapment efficiency, and particle size were selected as a response. The formulated microparticles were evaluated for particle size, drug-polymer compatibility study, aerodynamic behavior, morphology, particle size distribution, crystallinity, residual solvent content, in-vitro drug release study, and stability study. Results: By choosing the optimum spray drying conditions maximum yield of 73%, entrapment efficiency of 86% and particle size of 1.4 μm was attained of the optimized batch. Thus the results revealed that spherical microparticles are suitable for inhalation and sustained release for 12 h. Conclusion: The successful formulation and evaluation of dry powder could be used as an enhanced therapeutic alternative of the standard oral anti-tubercular regimen, rescuing oral dosing, shortening drug regimen and limiting toxicity. This will ultimately improve patient compliance and diminish the prevalence of MDR resistance. Tue, 01 Jan 2019 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/8172 2019-01-01T00:00:00Z