http://localhost:8080/xmlui/handle/123456789/7216 2026-04-05T17:42:05Z http://localhost:8080/xmlui/handle/123456789/8189 Nanoliposomal topical formulation for increasing safety and combating microbial drug resistance in leprosy SHAH, DEEP The aim of the present investigation was to develop and evaluate nanoliposomal topical spray for the improved treatment of leprosy. Dapsone and chaulmoogra oil can improve the leprosy condition if given in the form of nanoliposomal topical spray dosage form. Nanoliposomes were prepared using solvent injection method. The nanoliposomes dispersion was converted in the topical spray using simple dispersion method. Nanoliposomal topical simple spray was evaluated for particle size, percent drug entrapment efficiency, surface morphology, pH, drying test, volume per spray, area of film, in-vitro drug release study and stability study. Optimization parameters were done by 32 factorial design using design expert software 11.0.0 FTIR study shows that neither drug decomposition nor drug-excipients and excipient-excipient interactions occurred in the formulation. Analytical method was performed using UV spectroscopy. Nanoliposome was successfully prepared by optimizing Drug: Lipid ratio (1:7) and HSPC: Cholesterol ratio (7:3). Nanoliposomal topical spray prepared by lyophilized method. Nanoliposomal spray was prepared by using powder of nanoliposomes (100mg), PVP K 30 (10%), PEG 6000 (6%), Menthol (0.05%), Propylene Glycol (3%), Ethanol (36.5%) and distilled water (Q.S.). Particle size and percent drug entrapment were found before lyophilized and after lyophilized, 18.01 ± 0.21 nm and 87.71 ± 0.12% respectively. Transmission electron microscopy study indicates that the vesicles were found to be in spherical shape. Drying time, volume per spray, area of film and dose uniformity were found to be 280 Sec ± 0.002, 0.16ml ±0.021, 155.57 ± 0.012 cm2 and 0.15ml ± 0.0012 ml respectively which show good spray conditions on the leprosy affected area. In-vitro drug release of optimized batch was found to be 95.76 ± 0.32 % up to 24 hr. Stability study shows that dapsone and chaulmoogra oil loaded nanoliposomal topical spray was stable at accelerated condition up to 1 month. The present study demonstrated that, the nanoliposomal topical spray was efficient to improve the outer membrane permeability to combact microbial drug resistance and increasing safety in leprosy treatment. For Full Thesis Kindly contact to respective Library 2019-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7242 Devlopment and in-vitro evaluate medicated lollipop containing meclizine hydrochloride ZABIR, SHERASIYA Problem Statement: Motion sickness is a sensation of wooziness. Motion sickness is a common problem in people travelling by car, train, airplanes, and especially boats. Anyone can get it, but it is more common in children, pregnant women, and people taking certain medicines. Motion sickness can start suddenly, with a queasy feeling and cold sweats. It can then lead to dizziness and nausea and vomiting. Meclizine hydrochloride administration should be 6 to 8 h before travel starts or before the expected onset of motion sickness. Purpose: The purpose of this study was to resolved related problems, Meclizine acts as a central nervous system depressant. It continues being effective for eight to 24 hours. It may also be used to reduce dizziness and loss of balance caused by inner ear problems. Oral route Many drugs can be administered orally as liquids, capsules, tablets, or chewable tablets. Because the oral route is the most convenient and usually the safest and least expensive. Medicated lollipop having potential to drug delivery orally, therefore the purpose of this study was formulating medicated lollipop for the orally drug delivery of meclizine hydrochloride. Method: Medicated lollipop was prepared by using Required quantity of sugar syrup was prepared mixing sugar and water. sucrose was dissolved in small quantity of water and heated it to 110ºC till sucrose dissolves completely forming as clear viscous sucrose syrup.Then the sucrose syrup was poured into the corn syrup and heated to 160ºC till the colour changes to golden yellow. Flavour was added between 120ºC to 135ºC then temperature was down to 90ºC and drug, polymer and other ingredients were added and mixed it well. The prepared mixture was poured into the calibrated mould , After 1-2 hrs medicated lollipop was pealed out from the calibrated mould and evaluated. Result: The formulation containing Require quantity of sugar, corn syrup and HPMC K 100M with solvent used water contained was prepared medicated lollipop was the optimized batch with hardness11.8kg/cm2 and drug released study 96.69%.Stability study shows developed medicated lollipop was stable at 25º C ± 2º C at 50 ± 5% RH (Room Temperature) and 30º C ± 2º C at 65 ± 5% RH (accelerated condition) after One months. Conclusion: So, This Medicated lollipop formula (F8) is considered to be a potential vehicle for a meclizine hydrochloride for delivering drug orally. For Full Thesis Kindly contact to respective Library 2019-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7241 Local delivery of caffiene-loaded chitosan nanoparticles containing ethyl cellulose film for the enhanced treatment of periodontitis PATEL, VRUNDA Periodontal disease is a severe gum infection that damages the soft tissues and destroy the bone and supports your teeth. Periodontal Disease is very common and, is widely severe as the second most common disease worldwide. In the united states has a prevalence of 30-50% of the population, but about have severe form. This severe form is known as periodontitis. Caffeine shows antimicrobial and potent antioxidant activity and used to treat certain bacterial infection. Common side effect of caffeine includes Nausea, vomiting, hypertension, Rapid heartbeat and digestive issue. Nanoparticles loaded film contain chitosan and caffeine, Caffeine has a longer half-life 5-6 hours, Nanoparticles loaded film is much efficient to deliver small amount of Drug over prolonged period there by increasing patient compliance. Chitosan containing nanoparticles prepared by ionic gelation method. The Optimized batch of nanoparticles was evaluated for particle size, Zeta potential, Drug content, In-vitro Drug release study, antimicrobial study, and Transmission electron microscopy. Drug content and Drug release of optimized batch F3 were 86.40% and 89.30% respectively. Transmission electron microscopy (TEM) study shows that the particles size and Particle shape, after preparation of Nanoparticles they have loaded in film. Nanoparticles loaded film was prepared by solvent casting method using ethyl cellulose as polymer. The film was evaluated for thickness, weight uniformity, swelling index, folding endurance, surface pH, and surface morphology study with Gas chromatography, antibacterial study. Drug content and folding endurance of optimized batch were 81.22% and 312 respectively. Chitosan containing ethyl cellulose loaded film combination is the improved carrier including other preparation of caffeine periodontal film for prolonged the drug action up 7 days. For Full Thesis Kindly contact to respective Library 2019-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7240 Development and evaluation of fast dissolving oral films of meclizine HCL MALEK, RUBINABANU Vertigo is a very common disturbance of an inner ear that is caused by certain health conditions, medications, motion sickness. Most medications for motion sickness need to be taken at least 30 minutes prior exposure to the activity it will needs to solve problem. This project is based on the hypothesis that fast Dissolving Films are rapidly dissolving dosage forms which when placed in the mouth release the drug immediately. These dosage forms would be preferred by paediatric and geriatric patients since these are not associated with fear of choking. The fast dissolving films prepared by solvent casting method with suitable appearance, mechanical strength, peel ability and disintegration time were obtained using gelatine as a natural primary film former. Meclizine HCl, a poorly water soluble and bitter drug could be successfully incorporated in the fast dissolving films with the help of natural solubilizer such as dehydrated banana powder and PEG-400. For Full Thesis Kindly contact to respective Library 2019-04-01T00:00:00Z