http://localhost:8080/xmlui/handle/123456789/7306 2026-04-10T21:14:35Z 2026-04-10T21:14:35Z SONI, NEHA R. http://localhost:8080/xmlui/handle/123456789/7321 2020-11-07T06:36:54Z 2020-05-01T00:00:00Z

EFFECT OF GANGERUKI MALHAR IN THE MANAGEMENT OF GUDA VIDAR W.S.R. TO FISSURE IN ANO SONI, NEHA R. INTRODUCTION: The surgeon must therefore strive to maintain or to restore his patient’s health. In the era of fast food, there is change or irregularity in diet and diet timings and also sedentary life style. All these causes disturb in digestive system which results in too many diseases amongst them ano-rectal disorder constitute an important group. Acharaya Dalhana has described the term Guda Vidar as a condition of Guda in which there is cutting pain and tearing pain. Similarly, Jejjata and Todara have clearly described Guda Vidar as a condition which causes cutting pain in ano rectum. The factors responsible for causation of Guda Vidar as found in various texts are Vamana-Virechana-Vyapat, Bastikarma Vyapat, Atisara, Grahani, Arsha, Udavarta. AIM AND OBJECTIVES: AIM –To evaluate the efficacy of Gangeruki Malahar in the management of Guda Vidar (Acute Fissure-in-Ano). OBJECTIVES-To explore the possibilities of Gangeruki Malahar for local application as an effective, Safe, economical and simple therapy and short-term treatment for Guda Vidar (Acute Fissure-in-Ano). METHODOLOGY: It is a clinical study conducted on 30th patients, at Parul Ayurveda hospital. The treatment Protocol Gangeruki Malahar for local application of Guda Vidar (Acute Fissure in ano) in twice daily 7th days. Before and after 7th days treatment, all sine and symptoms heald of fissure Was assessed. Ethical clearance was obtained from institutional ethics Committee ABSTRACT (IEC No: PU/PIA/IECHR/2019/40) and this study is registered in Clinical Trial Registry of India. (C.T.R.I. No. CTRI/ 2019/08/020690). OBSERVATIONS & RESULTS: The Change in the before, after and follow up treatment were assessed by the Non parametric test .in this study 86.7% patients had shows healed fissure. And all symptoms are reduced.13.3% had marked improvement and over all average effect of the therapy 86.7%. CONCLUSION: 30 patients of Guda Vidar (Acute Fissure in Ano) were conducted for the clinical study, through specific observations, following conclusions are drawn. Gangeruki Malahar was found effective in relieving pain, bleeding, burning sensation, and healing of Guda Vidar (Acute Fissure in Ano). Burning sensation & bleeding can be effectively controlled within 2- 4 days application of Gangeruki Malahar. Gangeruki Malahar helps in relieving the sphincter spasm, also its contact with the lesion was there for longer duration, which helped in healing the fissure quickly. The therapy was well tolerated and there have been no complication found during the study. Gangeruki Malahar can be easily prepared, the technique of application is simple and also can be done as an out patient procedure. For Full Thesis Kindly contact to respective Library

2020-05-01T00:00:00Z Sonani, Snehal http://localhost:8080/xmlui/handle/123456789/7320 2020-11-07T06:34:45Z 2020-04-01T00:00:00Z

CLINICAL EVALUATION OF KATUPILA NIRUDHHALEPA IN MANAGEMENT OF DUSTHA VRANA Sonani, Snehal INTRODUCTION: Dustavrana (Chronic/ non-healing/ contaminated ulcer) is a frequently encountered problem in present era commonly as a complication of trauma and pathological insult. Ayurveda has mentioned Dusta Vrana and its management very broadly. Among that Vrana Shodhana and Vrana Ropna is a treatment modalities which is mentioned under the Shasti Upkramas. Number of drugs known to Ayurveda since Vedic era is increasing time to time. Aacharya Charaka states that one should get the knowledge about plants from tribal people or cowherds as they know and use the plants in a better way by experience. So this study includes a drug Katupila, which can be easily available to all people and useful for Vrana Shodhana and Ropana. AIM AND OBJECTIVES: Aim –To evaluate the efficacy of Katupilla Nirudhhalepa in the management of DustaVrana Objective – • To assess the pathophysiology of Dusta Vrana in context of Ayurvedic literature • To evaluate the mode of action of Katupilla Nirudhhalepa in the management of Dusta Vrana. • Pharmacological evaluation of Katupila • To observe and compare the available classical Dusta Vrana lakshna with available modern parameters for the chronic wound ABSTRACT METHODOLOGY: A Open single arm Clinical Trial Study on minimum 30 patients of Dusta Vrana were treated with local application of Katupila Nirudhhalepa (Katupila Patra Churna and Honey) once in a day for maximum 28 days or till complete wound healing whichever is earlier. Baseline Assessment was done on day 0, and then weekly progress was assessed over Vedana, Sraava, Kandu, Gandha, Varna, Akruti, Granulation and Slough and was noted in clinical case proforma and it was statistically analysed after completion of study. OBSERVATIONS & RESULTS: The Statistical test showed significant results in the assessment parameters in study. Hence, null hypothesis is rejected and Alternative Hypothesis i.e. Katupila Nirudhhalepa is effective in management of Dusta Vrana is accepted. CONCLUSION: • Even though, in classics only single Sloka is mentioned for Dustha vrana, Dustha Vrana can be classified in tar-tama bhav as per Doshika involvement. • Shodhana property of Katupilla Nirudhhalepa is established by absence of necessity of mechanical debridement in all the 30 patients, though they have reported with different grading of slough. • Ropana property is indicated by pharmacological evaluation, that it consists many of ingredient i.e. alkaloids, terpenoids, flavanoids etc and also antibacterial activity which are promoting factors for wound healing process. So, all observation and results showed that Katupila Nirudhhalepa is promoting agent in wound healing process. • Vrana is vast term including both wound and ulcer. And modern science has mentioned various type of non-healing, chronic and contaminated wound which can be considered under term Dusta Vrana. • No any adverse effects were noted during study, so conclusion can be drawn that, this combination is safe for local application in wound. For Full Thesis Kindly contact to respective Library

2020-04-01T00:00:00Z Saxena, Aprajita http://localhost:8080/xmlui/handle/123456789/7319 2020-11-07T06:30:16Z 2020-05-01T00:00:00Z

A Clinical and Comparative Analgesic study of Agnikarma with Thermal micro probe and Panchdhatu Shalaka in Osteoarthritis of Knee joint Saxena, Aprajita • INTRODUCTION: Osteoarthritis is an important cause of disability and 2nd most common musculoskeletal problem in the world (30%). Ayurveda has elicited the knee joint pain in the form of Janu Sandhigata vata which is a vata vyadi. Acharya Sushrut has mentioned Agnikarma among other treatment options for Snayu, Sandhi and Asthigata Vata. The pain caused by Janu sandhigata vata limits the activities of the person and degrades the quality of life of the able and working population. So, a convenient, easy and fast acting method to manage the pain in Janu Sandhigata vata is the need of the hour. Performing Agni karma with red hot metal Shalaka as described in Ayurvedic literature deters most patient from opting this procedure as it looks terrifying to the patient. Thus, opting for modified thermal micro probe could prove to be a better solution and might seem more approachable to the patient. The purpose of this study is to define, if indeed this modified technique delivers pain relief as observed in standard Agni karma technique in practice. AIM To evaluate the role and efficacy of Agnikarma with thermal micro probe in management of pain in osteoarthritis of knee. OBJECTIVES - To compare the effectiveness of Agni karma with thermal micro probe and with Panchadhatu Shalaka in the management of pain in Sandhigata vata with special reference to Osteoarthritis of knee. - To study the probable mode of action of heat (Agnikarma) in pain management. • METHODOLOGY: An Interventional study (Randomized controlled clinical trial).40 patients of Janu Sandhigata Vata were randomly divided into 2 groups. In group- A, Agnikarma was done with Panchdhatu shalaka and in group B with Thermal micro probe. Total 4 sittings of Agnikarma was done weekly. The assessment was made on Pain, Crepitus, Tenderness, Stiffness, Disability of the patient in daily routine activities, Range of movement and Swelling of the knee joint and were noted in clinical case proforma and it was statistically analysed after completion of study • OBSERVATIONS & RESULTS: Both groups showed significant results and on comparison there was insignificant difference. Thus, alternative hypothesis i.e. Thermal micro probe is effective on Osteoarthritic pain management is accepted. CONCLUSION: Agnikarma with Thermal micro probe showed almost equal results in pain management similar to Panchdhatu shalaka with no adverse effects. It is handy, attractive, more patient friendly and effective in Pain management. For Full Thesis Kindly contact to respective Library

2020-05-01T00:00:00Z KRISHNADEV, C.P. http://localhost:8080/xmlui/handle/123456789/7317 2020-11-07T06:27:16Z 2020-05-01T00:00:00Z

AN EXPERIMENTAL EVALUATION OF EFFECT OF SARPA NIRMOKA MASI ON VRANA KRISHNADEV, C.P. INTRODUCTION: In the present day scenario healing of wound has become a nightmare for both surgeon and sufferer. Even though many methods have been mentioned in the classics regarding the matter but lacks feasibility in present times hence, a more efficient drug have been selected from the classics which is not widely used due to the procurement ABSTRACT NAME OF GUIDE, DESIGNATION : Dr. Vivekanand kullolli, of its raw materials and modified to a form which makes it more efficient in less doses and a pre-clinical study was conducted to revalidate its efficacy in the new dosage form. AIM AND OBJECTIVES: • To evaluate the wound healing potentials of Sarpa Nirmoka Masi on Vrana by means of experimental study. • To evaluate the pharmacological action of Sarpa Nirmoka Masi. • To assess the cost effectiveness of Sarpa Nirmoka Masi. • To evaluate the effect of Sarpa Nirmoka Masi in different types of wound. METHODOLOGY: DESIGN: Open single arm experimental study SETTING: Animal house attached to the Parul institute of pharmacy SELECTION: A total of 8 adult healthy male wistar rats of 08-10 weeks old age were selected. The rat body weight was in the range of 260 to 290 gms. GROUPING: Total 8 Animals were procured for this study, which were divided consisting of 2 animals in each group (NORMAL, CONTROL, STANDARD, TRIAL-SHUDHA VRANA & DUSTA VRANA) PROCEDURE: A full thickness of the excision wound of approximate area of 700 sq.mm and 2mm depth were created along the markings with a surgical blade in control, standard and Trial groups INTERVENTION: Normal group: Not made any wound Control group: Wounds were left for natural healing without any medications Standard group: Wounds were treated with 5% povidone-iodine ointment Trial group (both Shudha Vrana and Dusta Vrana) : Wounds were treated with Sarpa Nirmoka Masi Film OBSERVATIONS & RESULTS: The days it took for the healthy granulation and epithelization to appear were 10 days in Shudha Vrana and 18 days on Dusta Vrana respectively. Where as it took 24 days in both Control and Standard groups. At the end of study Shudha Vrana and Dusta Vrana samples showed complete healing of wound on 14th and 18th day respectively. Where as it took Control and Standard groups 28 and 30 days. CONCLUSION: Sarpa Nirmoka Masi Film is effective in healing of Shudha Vrana and Dushta Vrana. For Full Thesis Kindly contact to respective Library

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