http://localhost:8080/xmlui/handle/123456789/7263 2026-04-05T17:41:30Z 2026-04-05T17:41:30Z PARMAR, DIPALBEN http://localhost:8080/xmlui/handle/123456789/7295 2020-11-07T05:40:18Z 2016-04-01T00:00:00Z

Analytical method development and validation for simultaneous estimation of clindamycin phosphate and benzoyl peroxide in combined dosage form PARMAR, DIPALBEN A Simple, accurate and precise UV Spectroscopic (First order derivative method) and RP-HPLC method were developed and validated for simultaneous estimation of Clindamycin phosphate and Benzoyl peroxide in combined dosage form. First order derivative method based on the measurement of absorbance at two wavelength 211 nm and 243 nm ZCP of BENZ and CLINDA respectively. The calibration curve was linear in a concentration range of 1.2-6 μg/ml for CLINDA and 3-15 μg/ml for BENZ. The RP-HPLC method has shown adequate separation of CLINDA and BENZ in combined dosage form. The separation was achieved on column Thermo BDS C18 (250 mm x 4.6 mm, i.d. 5 μm particle size) with mobile phase of Phosphate buffer (pH 4.5): Acetonitrile in the ratio of (50:50 v/v). The flow rate was 1.0 ml/min and detection wavelength was 210 nm. The retention time for BENZ and CLINDA was obtained 3.550 min and 5.187 min respectively. The linearity of the proposed method was in the range of 1.2-6 μg/ml and 3-15 μg/ml for CLINDA and BENZ respectively. Correlation coefficient was 0.9996 and 0.999 for CLINDA and BENZ respectively. The method was validated as per ICH Q2(R1) guidelines and acceptance criteria for linearity, recovery, precision, and robustness. The Forced degradation study was carried out as per ICH guideline under acidic, basic, oxidative, thermal and Photolytic conditions. All peaks of degraded product were resolved from the drug with different retention time effectively, as it employed as a stability indicating one. For Full Thesis Kindly contact to respective Library

2016-04-01T00:00:00Z VASHI, KALPESHKUMAR http://localhost:8080/xmlui/handle/123456789/7293 2020-11-07T05:36:19Z 2016-04-01T00:00:00Z

Formulation and evaluation of microsponge based drug delivery system for treatment of fungal infection VASHI, KALPESHKUMAR Fungal infection is common skin disease caused by fungus. Bifonazole has antifungal activity which act on fungal cell membrane and kill the fungi. Bifonazole microsponges were prepared using quasi-emulsion solvent diffusion method. Eudragit RS 100 polymer was used for the microsponge preparation. Microsponge formulations were evaluated for production yield, particle size, loading efficiency and scanning electron microscopy. Production yield, particle size and loading efficiency of M17 formulation were found to be 84.43±0.32%, 41.1μm and 89.49±0.30% respectively. Gel was prepared using carbopol 934 and different permeation enhancers were taken. Microsponge loaded gels were evaluated for viscosity, gelling strength, In-vitro diffusion and Ex-vivo permeability studies. Microsponge loaded gel, G7 formulation shows viscosity 4280±0.254 cps, Spreadability 11.32±0.057 gm.cm/s and drug content 85.30±0.191%. In-vitro Permeation of G7 formulation and marketed cream were found to be 80.29±2.98 and 57.18±2.42 respectively. Ex-vivo permeability of G7 formulation and marketed cream were found to be 76.13±2.96% and 52.67±32.48% respectively. The drug release data of G7 formulation were fitted into different kinetic models, which show that the drug release follows first order release. G7 formulation was compared with the marketed cream for antifungal activity. The result shows that the G7 formulation having good antifungal activity than the marketed formulation. Skin irritation studies and stability testing of G7 formulation were carried out and the results were found satisfactory. In conclusion, Microsponge loaded gel was gives higher permeability and sustained release of drug topically. Microsponge loaded gel was minimized the drawbacks associated with the marketed cream. For Full Thesis Kindly contact to respective Library

2016-04-01T00:00:00Z Shah, Pratikkumar http://localhost:8080/xmlui/handle/123456789/7288 2020-11-07T05:24:37Z 2016-04-01T00:00:00Z

Colon targeted drug delivery system of capecitabine for treatment of colorectal cancer Shah, Pratikkumar Colorectal cancer as the common malignant tumor in digestive tract is seriously threatening the health of human beings. With the development of medicine, current treatment for colorectal cancer has gradually diversified. Targeted therapy is a kind of therapy that combines therapy drug with drug carrier system, delivering the drug to specific target organs to play the curative effect under the function of specificoriented mechanism. Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of numerous cancers. It has been used in the treatment of colorectal, breast, gastric and oespphageal cancer. The purpose of present investigation was to develop colon targeting tablet of capecitabine for colorectal cancer targeting. Capecitabine is anti-metabolite which enzymatically convert to 5- flurouracil by two step in present of enzyme cytidine deaminase and thymidine phosphorylase. Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry had employed to study drug-excipients incompatibility. Capecitabine colon targeted tablets were prepared using wet granulation method. Optimization of formulation was done by 32 full factorial design using Design Expert software. The pre-formulation study shows that neither drug nor any excipients interact with each other. Different pre-compression and post compression parameters had been carried out to optimize the formulation. In-Vitro drug dissolution and bio-relevant drug dissolution study were carried out which shows 98.835 ±0.390% and 97.650±0.652% after 345 min. drug release at colonic pH. Bio-relevant drug dissolution study was carried out for comparison with marketed product which demonstrates that colon targeting tablet had good drug dissolution compared to marketed product. Stability study shows Colon targeted capecitabine tablet was stable at accelerated condition. The present study demonstrated that Colon targeted capecitabine tablet is suitable for colon targeting drug delivery and had great potential for targeting colorectal cancer. For Full Thesis Kindly contact to respective Library

2016-04-01T00:00:00Z RANA, PARTH http://localhost:8080/xmlui/handle/123456789/7285 2020-11-07T05:20:50Z 2016-04-01T00:00:00Z

Formulation and evaluation of mucoadhesive in situ nasal gel of cylobenzaprine hydrochloride RANA, PARTH The aim of the study was to formulate and develop Thermoreversible nasal in situ gel of Cyclobenzaprine hydrochloride by cold method which may improving the bioavailability and avoidance of the first pass metabolism. Drug excipient compatibility study was carried out using Fourier transform infrared spectroscopy which shows that neither drug decomposition nor drug-excipients and excipients-excipients interactions occurred in the formulation. Thermoreversible nasal in situ gel of Cyclobenzaprine hydrochloride containing Poloxamer 407 was used as the gelling agent gives excellent thermo sensitive gelling effect and Hydroxyl Propyl Methyl Cellulose K4M was used as a mucoadhesive Polymer gives good mucoadhesivity to the formulation and increase nasal residence time of the formulation. Quick release of drug was achieved by PEG 400 used as a permeation enhancer. 32 Factorial designs were apply for optimization of the concentration of HPMCK4M and PEG400. In situ gel based formulation of Cyclobenzaprine Hydrochloride was evaluated for clarity, pH ,Drug Content ,Gelling Temperature, mucoadhesive force,% drug release ,histopathological study and stability study. An optimized formulation containing 18% poloxamer 407 , 0.4 % HPMCK4M and 1% PEG was found to be good in terms of clarity, pH (5.8), gelation temperature (320C), mucoadhesive force (736 Dyne/cm2), Drug content (96.87),% Cumulative drug released (94.05% in 5 hr with a flux of 0.122 mg/cm2/min) and had no cellular damage as indicated by histopathological study. The optimized formulation was stable for 21 days in accelerated conditions. For Full Thesis Kindly contact to respective Library

2016-04-01T00:00:00Z