Kayachikitsa

An open label pilot study of kalyanaka ghrita in the management of obsessive compulsive disorder

2020-11-26T08:58:00Z

An open label pilot study of kalyanaka ghrita in the management of obsessive compulsive disorder RAJPUT, PURVI Background: Obsesseive and Compulsive Disorder or OCD is a heterogeneous and multidimensional disorder. The lifetime prevalence of OCD in general population is 2-3%. This is the fourth most common psychiatric diagnosis. It constitutes 10% of psychiatric OPD. The Standard or proven drug for the OCD is yet to explored in the field of Ayurveda, though few studies has been conducted but outcomes are not satisfactory. Objective: To evaluate the efficacy of Kalyanaka Ghrita in the management of Obsessive Compulsive Disorder. Method: Ethical clearance: Ethical clearance was obtained from Institutional Ethics Committee of Parul Institute of Ayurved, Parul University, Vadodara – 391760. Vide Ref- PIA/IECHR/2016-17/KC/04 dated 22/10/16. 10 patients of OCD satisfying the DSM-IV diagnostic criteria were selected. Kalyanaka Ghrita was administered to all for 60 days of period. The use of drug is in practice since very long, explained in Ayurvedic classics for various diseases, especially in Unmada. This drug was given for 60 days and patient then followed for one more month. There were total three assessments done before treatment, after treatment and after follow up. Yale Brown Obsessive Compulsive scale (Y-BOCS) was the selected for the measurement and Yale Brown Obsessive Compulsive symptoms checklist was selected to identify the symptoms. Results: Contamination Obsession, Symmetrical Obsession, Religious Obsession, Cleaning/Washing Compulsions, checking compulsions, Counting Compulsion, Ordering/Arranging Compulsions are the commonest symptoms of clinical presentation of OCD. Paired‘t’ test was used for statistical evaluation. 44.21% of relief was highly significant on reducing the symptoms of OCD on Y-BOCS (p<0.001). Interpretation: By understanding of Etiology, Symptomatology, Pathology, Course of Disease, Prognosis and Co-morbidity of OCD- the most suitable resemblance of OCD in Ayurveda is Grahonmada or Bhootonmada, no any other conditions. In present study it was found that almost every patients responded positively in short course of treatment and the positive effect the continued even after stopping the treatment in follow up period this may be because of long term and cumulative effect of the drug. After the complete follow up period the overall reduction of all symptoms was highly significant (about 44% reduction on Y-BOCS Score). This suggests Kalyanaka Ghrita is Highly Significant in the management of OCD. Conclusion: It is concluded that the efficacy of Kalyanaka Ghrita is statistically and clinically significant in the management of Obsessive Compulsive Disorder. For Full Thesis Kindly contact to respective Library

A clinical study on the management of diabetic polyneuropathy with rasayan vati

2020-11-26T08:54:37Z

A clinical study on the management of diabetic polyneuropathy with rasayan vati Kanase, Pallavi : Diabetic Polyneuropathy is one of the most common troublesome micro vascular complications of diabetes mellitus. It is nerve damaging disorders which are result in metabolic as well as vascular degeneration of neuron resulting in impaired nerve conduction. This neuropathy is leading independent risk factors (Hypertension, dyslipidemia, obesity, and cigarette smoking) for mortality and morbidity as a result of foot ulceration and non traumatic amputation of lower limb extremities. This makes the patient permanently immobile. In Ayurveda, although there is no direct correlation for Diabetic Polyneuropathy but the basic Most of the symptoms mentioned under purvaroopa and upadrava of Prameha such as pada daha, padasuptata, and shoola similar to diabetic Polyneuropathy symptoms. Pathology behind it is can be studied under madhumeha upadrava caused by Avarana janya vata prakopa. Hence in diabetics, prevention and management of Polyneuropathy is of utmost importance. This condition is well managed by Ayurveda with effectively and less cost. Materials and Methods: It is a clinical study with pre- test and post- test design conducted in single group. Rasayana Vati was given in a dose of 500mg 2 tablets twice in a daily for a period of 8 weeks. All the patients were followed up for a period of 4 week and assessment was done on the basis of subjective criteria (NSS and MNSI) and objective (Agni, Deha, Satwa bala and WHO QoL-BREF) criteria. Ethical clearance was obtained from Institutional Ethics Committee (IEC No. -PU/PIA/IECHR/KC/03), and this study is registered in Clinical Trial Registry of India (CTRI/2017/07/009075). Results : The change in the values before and after treatment were assessed by the paired‘t’ test. Statistically highly significant result was obtained in NSS (89.86%), MNSI-A (64.69%) and MNSI-B (71.69%). Discussion : Diabetic Polyneuropathy is a sequel to madhumeha which occurs due to further vitiation of doshas or due to vyadhi karshana. Diabetic Polyneuropathy is believed to occur due to Avrana janya vata prakopa. Vitiated vata damages nervous tissues by local inflammatory process (shoth) simultaneously Avrana causes sroto avrodh(obstruction in micro channels) which lead to malformation of preceding dhatu( progressive nutrition of tissues) leads to further dhatu kshya( emaciation at tissue level as well as at micro levels).which is produces symptoms like daha (burning sensation), suptata (numbness), harsha (tingling sensation), shosha (wasting), and dourbalya (weakness). This condition is well managed by Rasayana. Rasayan vati have property of Rasayana (Rejuvination), which act at the level of dhatu (body tissue), agni (metabolic activities), srotas (microcirculation). Rasayan vati contents anabhishyandi dravyas dominanted by singdha guna which acts as vata shaman, kapha-pitta avirodhi and srotoshodhana which clutches the samprapti of Avarana of vata. Conclusion : The hypothesis that the trial drug ‘Rasayana vati’ has beneficial effects on Diabetic Polyneuropathy is accepted and the null hypothesis is rejected. For Full Thesis Kindly contact to respective Library

Comparative clinical study on effects of praval pishti along with allopathic antihypertensive drug in the management of essential hypertension

2020-11-25T06:33:11Z

Comparative clinical study on effects of praval pishti along with allopathic antihypertensive drug in the management of essential hypertension JOSHI, SWANAND NA For Full Thesis Kindly contact to respective Library

A comparative clinical study on the role of Pratimarsha Nasya and Shiroabhyanga with Yashtimadhukadya Taila in the management of Khalitya (Alopecia)

2020-11-25T06:30:47Z

A comparative clinical study on the role of Pratimarsha Nasya and Shiroabhyanga with Yashtimadhukadya Taila in the management of Khalitya (Alopecia) Barad, Rahul NA For Full Thesis Kindly contact to respective Library